CBD FAQ Get answers to the most popular CBD questions

We interviewed Austin Flohrschutz, Director of Science for TruPotency, about the most popular CBD questions.

What are the side effects of CBD?

Many clinical trials show no side effects for CBD, but when they are reported the side effects tend to be very mild and many times the placebo group has almost as high or even the same side effects. Side effects that may happen include decreased/increased appetite, tiredness, and diarrhea. However, this should not be a concern for most people. 

Is it possible to overdose from CBD?

It would be very hard to overdose on CBD. Clinical trials have used 800 mg up to 1500 mg a day with no fear of overdosing. GW pharmaceuticals, the maker of a CBD seizure medication called Epidiolex, suggests an upper limit of 20 milligrams of CBD per kilogram of body weight per day (20 mg/kg). For a 150-pound person this would equate to about 1400 mg a day, but that does not mean that taking more means you are overdosing. However some studies have used up to 50 mg/kg which would make that 1400 mg turn into 3500 mg, an exceptionally high dose. There is some cause for concern with the liver with more information on below. 

Can you have a withdrawal from CBD?

There has been no withdrawal reported for CBD and it may even help with withdrawal symptoms from various drugs of abuse, such as alcohol and opioid abuse. 

Can you get addicted to CBD?

CBD is non-addictive and may actually be beneficial for those struggling with addiction. Pre-clinical and clinical trials have found no drug reinforcement properties associated with CBD. 

How does CBD help with drug/alcohol addiction?

There are a few different thoughts here, but one of the major aspects of quitting a drug of abuse is dealing with the withdrawal symptoms, including anxiety and intrusive thoughts associated with the substance. CBD seems to help reduce this anxiety and other withdrawal symptoms to help get past the first stage of quitting an abusive substance. 

CBD also seems to help with relapse for similar reasons. It helps to control mood and anxiety associated with drug use, so the thoughts of using the drug are not as strong or intrusive to your daily life. Emotional issues are one reason people will self medicate and become addicted, so if CBD will help someone manage anxiety or mood problems, then it can help avoid feeling the need to self medicate on dangerous substances.

Pain is also a common withdrawal symptom, especially associated with opioid withdrawal. CBD can help reduce this pain and help control normal every pain as well. There are many clinical trials currently for substance use disorders, so we are waiting to learn more. 

Can CBD cause liver damage?

There is a somewhat recent scare from a published study suggesting CBD causes liver toxicity. ProjectCBD has a great overview of why this study is flawed, but we can turn the alarm off about this subject. When converting from animal dosages to humans, the study used dosages where the lowest dose was at the upper end of recommendations for humans. The highest dose (2460 mg/kg) when converted is roughly 10 times the maximum recommended dosage for humans.

So they are using dosing that is unrealistic to a real world situation. Another point is that over the counter medications, like acetaminophen (Tylenol), can cause very severe liver failure at high dosages, yet are available to anyone at most stores, and not to mention alcohol and all the liver and other issues associated with that. 

There is some concern with the liver and CBD though. CBD can inhibit the breakdown of other medication you are taking, effectively increasing the amount of the drug in your body, which could then cause liver toxicity. This is the same reason some medications will tell you to avoid grapefruit juice. So if you are taking medications, like blood thinners, you should talk to your doctor about using CBD along with your medication, so they can monitor your health. 

Will CBD oil make me tired?

Most likely, CBD will NOT make you tired. Some people have reported this side effect at large doses, but generally speaking CBD is not similar to THC in this regard. CBD can help with sleep, but is not a sedative, like standard sleeping medications. CBD can help you rest easier if you have problems with anxiety and intrusive thoughts that keep you up at night or pain that keeps you from getting comfortable in bed. 

Will CBD oil help sciatica?

Although I am not aware of any studies specifically looking at sciatica, CBD may help with this type of pain, called neuropathic pain. One study suggests CBD helps with both neuropathic pain and anxiety relief though serotonin receptor activation. Another study suggest similar neuropathic relief in chemotherapy model of neuropathy. So, although there is nothing conclusive, the data is promising. 

Can CBD help lower blood pressure? If so, how?

CBD may help reduce blood pressure. You will see a common theme as to how CBD is working because we don’t really know how CBD is causing its effects. There are some hypotheses out there as to how CBD is interacting with the body, but no clear picture has been made yet.

What medications should you not take while on CBD?

MedlinePlus is a government website that shows CBD’s major medication interactions with Clobazam and Valproate along with other moderate/minor interactions. One study specifically looked at warfarin (a blood thinner), which may be a dangerous interaction as well. Drugs.com suggests a slightly larger list of 24 medication with major interactions, but check with your doctor and ask if you should avoid grapefruit juice while on your medications. If the answer is yes, then you should probably avoid CBD as well. 

How does CBD oil help with epilepsy?

Unfortunately, how CBD actually works is a bit of a mystery. There are some hypotheses out there as to how CBD is interacting with the body, but no clear picture has been made yet. GW pharmaceuticals (maker of the CBD medication for seizures called Epidiolex) even states this on their website in a section directed at doctors and healthcare professionals. 

Many pharmacologist and related researchers are working diligently to figure this out. However I do want to make the point that although we know how 99%+ drugs work, there is one very common drug most people have used that we have no clue how it is working: acetaminophen (Tylenol). So just because we don’t know exactly how a drug is working, doesn’t mean we can’t or shouldn’t use it. 

How do CBD topicals work?

CBD is thought to help with skin due to its anti-inflammation and antioxidant properties. So it can be good for overall skin health, but has been looked at for certain skin ailments like psoriasis.

For facial use, CBD has been suggested to inhibit the sebum production of sebocytes. Sebum is a form of oil and overproduction can exacerbate acne. So reduced oil along with anti-inflammatory properties can help improve acne. CBD facial skincare products might start to become a more popular for daily facial care routines. 

Topical CBD is probably not getting through the skin at any appreciable level, so while oral CBD might be good for anxiety, topical CBD won’t really be affecting your brain. Enough can potentially get through for local pain and inflammation relief, so creams or balms may be beneficial to some. Though there are transdermal products, which are designed with skin penetration enhancers to assist in delivering CBD (or other drugs) into the body through the skin. 

Can CBD oil help with diverticulitis?

Although I am not very familiar with this disease, it seems to be heavily associated with inflammation. CBD can help with the inflammation, but I would not say it would be a treatment or cure for diverticulitis. Check with your doctor as they might prescribe antibiotics or other treatments for this. 

Will CBD oil help with idiopathic pulmonary fibrosis?

This is another disease I am not very familiar with, but CBD might help with inflammation associated with the disease, although by no means does that suggest a cure. There are two somewhat new medications currently available to those who suffer with IPF, so check with your doctor to see if those may be a choice for you. 

Is full spectrum CBD better than broad spectrum or isolate-based CBD? If so, why?

I always recommend full-spectrum CBD products. However consuming small amounts of THC can be an issue for some people, either because they are very sensitive to THC or they have to take drug tests. Generally speaking though, the closer you get to the full plant extract the greater enhancement from the entourage effect you will have for therapeutic potential. Ethan Russo wrote an updated article on the entourage effect in 2019 that is a great read. 

Broad-spectrum is close to full spectrum and you will probably still get some synergistic, but not quite as potent as full-spectrum. From a therapeutic potential aspect CBD isolate probably has the least benefits all alone, but still is a very fine molecule that can help children reduce their daily seizures and improve their quality of life.

Where can you get high quality CBD products?

With over 1000 new CBD brands created in 2019 it is hard for consumers to know if a company is legitimate or just jumping on the CBD hype bandwagon to make a quick buck. TruPotency has assembled a diverse science advisory board of PhD scientists, doctors, and wellness professionals to push the boundaries of our scientific understanding.

Our common thread is the study of cannabinoids and drug interactions within the body. From neuroscience, to cancer research, to dermatology, and plant microbiology, our collective goal is to use our knowledge to bring you the purest, most effective and safe cannabinoid products.

It’s not just about making sure a bottle has the labeled amount of cannabinoids. It’s also about testing for pesticides that could come from questionable growing practices, heavy metals from bad extraction techniques, and molds that can show up in organic material. No one has been willing to be a watchdog, so we are motivated to take on this task.

Why CBD?

December 28, 2019

Author: Lori Bouchie So why did I start this journey?  My son started a company, he’s an entrepreneur, a word that is foreign to my generation.  He’s always been one step ahead in thinking than any of us.  He comes up with things that we have always said, “gee I wish I would have thought…

Ways Athletes Can Use CBD for Recovery

October 23, 2019

Author: Jason Beverly “No Pain, No Gain” is a universal phrase commonly used by all types of athletes who strive to push their minds and bodies beyond their limits. It does not matter what type of sport or activity – it’s a fact that being an athlete means you will experience pain. There is no…

Tips on How to Find and Choose Vegan CBD Products

March 11, 2020

Author: Alex Malkin CBD is a booming industry, and this is great for consumers. Never before have we had so many different vegan CBD products to help us live healthier and happier lives. With so many different producers and products on the market, let find some great vegan CBD products with this vegan CBD buying…

All you need to know about cannabis oils, concentrates, and extracts

April 15, 2020

Author: Janet Dahlen It is worth knowing that cannabis oils, concentrates, and extracts can provide you with many excellent benefits that you will not get from smoking. They are not only easy for precise dosing but also have refined flavors. Those products are focused on the finest ingredients of cannabis. You can get them in…

What is CBD?

October 12, 2018

Author: Joy Hughes It seems everyone is talking about Cannabidiol (CBD), a chemical compound that has shown promise for its therapeutic effects on a number of ailments. Let’s explore what CBD is, its history, how it works in the body, potential health benefits, and the legal implications of using it. CBD Definition Cannabidiol (CBD) is…

5 Benefits of CBD for Cats & Dogs

August 13, 2019

Author: Kathy Cooley After years of struggle to step out of the drug image, cannabis is finally receiving all the praises it deserves. The medical community is widely supporting the launch of medical cannabis, and cannabis-infused products that promise to heal and lead away to a healthy lifestyle. Across the world, scientists are researching more…

CBD and Exercise: Separating Fact from Fiction

April 16, 2020

Author: Nemanja Exercising is one of the best things to do in spare time because after all, there are so many well-documented benefits to regular physical activity. Still, it’s essential to choose the right type of workout, so you’ll be able to feel comfortable and productive every time you decide to exercise. Not all people…

10 Best High CBD Flower Strains

May 28, 2020

Author: Jason Beverly High CBD hemp flower has been gaining a lot of popularity lately. People are learning that there are many different ways to consume CBD. If you’ve never smoked CBD flower or bud, you’ll come to learn that it’s very similar to smoking marijuana, but without the high. High CBD flower strains are…

How does CBD interact with medications?

January 16, 2019

Author: Joy Hughes When ingesting CBD, it first must metabolize through the digestive system and then filter through the liver. It is in the liver that CBD, along with other medications, must filter through a system known as the cytochrome P450 (CYP 450) — a family of various enzymes. It is through this system that drugs…

Hemp Crop Insurance in 2020

February 21, 2020

Author: Jason Beverly Federal authorities from the USDA’s Risk Management Agency (RMA) recently announced that some industrial hemp farmers will have the opportunity to get insurance under the Whole-Farm Revenue Protection (WFRP) program in 2020. This pilot program is specifically for hemp farmers growing hemp for the purpose of fiber, grain, seeds, flower and CBD…